Asymmetric cell division: a persistent issue?
نویسندگان
چکیده
Heterogeneity within a clonal population of cells can increase survival in the face of environmental stress. In a recent issue of Science, Aldridge et al. (2012) demonstrate that cell division in mycobacteria is asymmetric, producing daughter cells that differ in size, growth rate, and susceptibility to antibiotics.
منابع مشابه
Advocating Asymmetry and the POP-1 Paradox: Noncanonical Wnt Signaling in C. elegans
In this issue of Cell, Kidd and colleagues (Kidd et al., 2005) describe their identification of a novel beta-catenin that functions in noncanonical C. elegans Wnt signaling pathways to specify the different fates of daughter cells produced by asymmetric cell division.
متن کاملThe Simple Life (of Cortical Progenitors)
Asymmetric cell division plays a major role in the generation of cell diversity during development. In this issue of Neuron, Sun and colleagues present evidence that the epidermal growth factor receptor is asymmetrically distributed in mitotic cerebral cortical precursors, and the resulting unequal inheritance generates offspring with different responsiveness to growth factor and unique cell fa...
متن کاملConnecting Cancer to the Asymmetric Division of Stem Cells
Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.
متن کاملSnapping magnetosome chains by asymmetric cell division in magnetotactic bacteria.
The mechanism by which prokaryotic cells organize and segregate their intracellular organelles during cell division has recently been the subject of substantial interest. Unlike other microorganisms, magnetotactic bacteria (MTB) form internal magnets (known as magnetosome chain) for magnetic orientation, and thus face an additional challenge of dividing and equipartitioning this magnetic recept...
متن کاملAsymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
The stem cell-intrinsic model of self-renewal via asymmetric cell division (ACD) posits that fate determinants be partitioned unequally between daughter cells to either activate or suppress the stemness state. ACD is a purported mechanism by which hematopoietic stem cells (HSCs) self-renew, but definitive evidence for this cellular process remains open to conjecture. To address this issue, we c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Developmental cell
دوره 22 2 شماره
صفحات -
تاریخ انتشار 2012